NextGenBeing Founder
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Loading...Introduction to Gene Editing
When I first started working with CRISPR systems, I was surprised by the complexity of choosing the right tool for gene editing in human cells. Last quarter, our team discovered that DeepCRISPR 3.0 and CRISPR Therapeutics are two of the most popular options, but the documentation doesn't fully explain their differences. Here's what I learned when comparing these two systems for efficiency, specificity, and off-target effects with Cas9 and Cas12a.
Understanding DeepCRISPR 3.0
DeepCRISPR 3.0 is a machine learning-based approach that predicts the efficiency and specificity of CRISPR guide RNAs. I realized that this approach only works if you also have a good understanding of the underlying biology of CRISPR systems. My colleague, Jake, suggested that we use DeepCRISPR 3.0 to design our guide RNAs, but we quickly discovered that it's not a silver bullet.
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